DNA compaction

From ResearchID.org, a nexus for researching Intelligent Design

A typical artistic rendition of DNA compaction --- source
A typical artistic rendition of DNA compaction --- source

The structure of the DNA within the cell, as explained by most textbooks, is a caricature of its actual compaction and structure. In a eukaryotic cell, the DNA undergoes many levels of twisting, folding, rolling, twirling, and coiling. Given the dense and complex compaction DNA undergoes, only providing a summary in a textbook is understandable.

Here is a brief sketch: DNA forms a double-helix that is wrapped around a histone that is bundled into a nucleosome which makes chains of a nucleosomal array which is held together by linker histones to form chromatin fibers and the chromatin scaffolding that takes its shape with the help of the nuclear matrix which allows chromatin scaffolding loops to become a supercoil that makes up a chromosome which is the genetic material that is in the nucleolus which in turn is in the nucleus which is in a cell.

Let's unpack this system with some of the detail it deserves.

Contents

DNA

Deoxyribonucleic Acid (DNA) --- source
Deoxyribonucleic Acid (DNA) --- source

Deoxyribonucleic acid (DNA) is a nucleic acid that contains the genetic instructions specifying the biological development of all cellular forms of life, and most viruses. DNA is a long polymer of nucleotides and encodes the sequence of the amino acid residues in proteins using the genetic code, a triplet code of nucleotides.

DNA is often referred to as the molecule of heredity as it is responsible for the genetic propagation of most inherited traits. Each strand of DNA is a chain of chemical "building blocks", called nucleotides, of which there are four types: adenine (abbreviated A), cytosine (C), guanine (G) and thymine (T).

Double-helix

Double-helix structure of DNA --- source
Double-helix structure of DNA --- source

The DNA double helix typically consists geometrically of two congruent helices with the same axis, differing by a translation along the axis.

Histone

Histone
Histone

Nucleosome

Nucleosomes are made from histones --- source
Nucleosomes are made from histones --- source
Nucleosome core particle --- source
Nucleosome core particle --- source

Nucleosomal array

Nucleosomal array --- source
Nucleosomal array --- source

Condensed nucleosomes

Linker histones

Chromatin

Chromatin fibers --- source
Chromatin fibers --- source

Chromatin scaffolding

Image:Chromatin scaffolding.jpg
Chromatin scaffolding

Nuclear matrix

Nuclear matrix --- source
Nuclear matrix --- source

Chromatin scaffolding loops

Chromatin scaffolding loop --- source
Chromatin scaffolding loop --- source

Supercoil

Chromosome

A chromosome --- source
A chromosome --- source

Genetic material

Nucleolus

Nucleus

Nucleus --- source
Nucleus --- source

Cell

Eukaryotic Cell --- source
Eukaryotic Cell --- source

See Also