Error correction
From ResearchID.org
Error correction is maintained in the genetic code through mechanisms in the cell that check and recheck copies of the genetic code. When an error is found, there are other mechanisms that work to fix the problem. These mechanisms are critically important to computational and biotic processes. Human genome processing exhibits error rates of less than 1 in a billion.
Contents |
Error Correction in biology
Manish Gupta reviews error correction in biology. [1] May et al. discuss error-control coding.[2] Battail reviews error correcting codes.[3]
Proofreading
MacDónaill Nucleotide Parity code
In 2002, Dónall A. MacDónaill discovered in the nucleotide alphabet a binary (4,4,2) even parity code.[4][5][6] Gonzalez et al. address error correction and detection.[7]
Aminoacyl tRNA synthetases
Praetorius-Ibba et al. address Quality Control During Aminoacyl-tRNA Synthesis.[8] Transcription fidelity depends on: 1) specificity selecting the 20 member aminoacyl-tRNA synthetases (aaRSs), screening by elongation factor Tu (EF-Tu), following by possible further checking at the ribosome.
Aminoacyl-tRNA selection specificity
Cognate amino acid/tRNA pair synthesis
Proofing/Screening by elongation factor Tu
Ribosome checking/exclusion
AGT
References and notes
- ↑ Gupta, M. K., The quest for error correction in biology. Recent developments in codes and biology.IEEE Eng Med Biol Mag. 2006 Jan-Feb ; 25(1): 46-53
- ↑ May EE, Vouk MA, Bitzer DL, Classification of Escherichia coli K-12 ribosome binding sites. An error-control coding model. IEEE Eng Med Biol Mag. 2006 Jan-Feb ; 25(1): 90-7
- ↑ Battail, G., Should genetics get an information-theoretic education? Genomes as error-correcting codes.IEEE Eng Med Biol Mag. 2006 Jan-Feb ; 25(1): 34-45
- ↑ MacDónaill DA, A parity code interpretation of nucleotide alphabet composition, Chem. Comm. (2002) 2062-2063 [D.A. Mac Dónaill].
- ↑ MacDónaill DA, Why Nature Chose A, C, G and U/T: An Error-Coding Perspective of Nucleotide Alphabet Composition, Origins of Life and Evolution of Biospheres, Volume 33, Numbers 4-5 / October, 2003, 433-455
- ↑ MacDónaill DA, Digital parity and the composition of the nucleotide alphabet. Shaping the alphabet with error coding. IEEE Eng Med Biol Mag. 2006 Jan-Feb ; 25(1): 54-61
- ↑ Gonzalez DL, Giannerini S, Rosa R, Detecting structure in parity binary sequences. Error correction and detection in DNA. IEEE Eng Med Biol Mag. 2006 Jan-Feb ; 25(1): 69-81
- ↑ M. Praetorius-Ibba,,S. Ataide, C. Hausmann,, J. Levengood, J. Ling, S. Wang, H. ROy, & M. Ibba, Quality Control During Aminoacyl-tRNA Synthesis, Kem. Ind. 55(3)12999-134(2006)
- ↑ See Clarke ND (2004) "DNA binding and nucleotide flipping by the human DNA repair protein AGT." Nature structural & molecular biology 2004 Aug;11(8):714-20.
External Links
Error correction links
- DNA repair Wikipedia article
- Dónall A. MacDónaill faculty page
- Manish K. Gupta, List of publications
- Propellor twist
- [Human DNA repair genes http://www.cgal.icnet.uk/DNA_Repair_Genes.html Human DNA repair genes] supplement to the review by Wood RD, Mitchell M, & Lindahl T published in Mutation Research, 2005.
- DNA repair at The Gene Ontology Consortium
- PubMed search for 'dna error correction'
- Error correction: Google Scholar
Aminoacyl-tRNA Synthetase links
Proofreading links
- Unusual Mechanism Keeps Repair Protein Accurate DNA polymerase lambda research led by Zucai Suo
- Proofreading aminoacyl trna synthetase: Google Scholar
- Proofreading synthetase: Google Scholar
- PubMed (Search for: "proofreading", or "aminoacyl trna synthetase")
